Phenotypes Associated with This Genotype

Genotype
MGI:3814365

• Allelic Composition: Brca2^tm1Mbn/Brca2⁺
• Genetic Background: B6.Cg-Brca2^tm1Mbn Apc^Min

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:67445 )

N • body weight of mice at time of sacrifice does not differ significantly from Apc-heterozygous or wild-type animals; weight gain over experiment duration is similar to that of wild-type animals

integument

increased mammary gland tumor incidence ( J:67445 )

♀ • females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5

♀ • no males develop mammary tumors

reproductive system

reproductive system phenotype ( J:67445 )

N • only observed in 1/10 ENU-treated males, similar to wild-type males (1/9)

neoplasm

increased mammary gland tumor incidence ( J:67445 )

♀ • females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5

♀ • no males develop mammary tumors

endocrine/exocrine glands

adrenal gland hyperplasia ( J:67445 )

♀ • females exhibit some adrenal hyperplasia, while none is observed in males

increased mammary gland tumor incidence ( J:67445 )

♀ • females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5

♀ • no males develop mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:67445