Phenotypes Associated with This Genotype

Genotype
MGI:3814436

• Allelic Composition: Kras^tm2Tyj/Kras⁺; Trp53^tm1Glo/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:129627 )

• average lifespan is 266 days with female mice exhibiting shorter lifespans than male mice

neoplasm

increased metastatic potential ( J:129627 )

• lung adenocarcinomas and mesothelioma are highly invasive and metastatic with metastatic lesions observed in the lymph nodes and liver

• 19 of 52 mice with lung adenocarcinomas exhibit metastasis compared to only 2 of 44 Kras^tm2Tyj heterozygotes

abnormal tumor morphology ( J:129627 )

• 81.8% of mice with end-stage lung adenocarcinomas exhibit loss of heterozygosity of the Trp53 wild-type allele

increased tumor incidence ( J:129627 )

• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, pancreatic carcinomas, squamous carcinomas, and papillomas

increased lung adenoma incidence ( J:129627 )

• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas

• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated

increased lymphoma incidence ( J:129627 )

• some mice develop lung lymphomas

increased squamous cell carcinoma incidence ( J:129627 )

increased fibrosarcoma incidence ( J:129627 )

increased hemangiosarcoma incidence ( J:129627 )

increased mesothelioma incidence ( J:129627 )

• 13 of 56 mice develop mesothelioma 6 of which are peritoneal mesotheliomas

increased papilloma incidence ( J:129627 )

respiratory system

increased lung adenoma incidence ( J:129627 )

• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas

• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:129627