Phenotypes Associated with This Genotype

Genotype
MGI:3814533

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA succumb to skin and lung cancers (18/42 mice) with median survival of 28.6 weeks compared to wild-type mice which remain cancer-free for >40 weeks

digestive/alimentary system

gastrointestinal tract polyps ( J:78818 )

• polyps are present throughout gastrointestinal tract, including the stomach and colon

colon polyps ( J:78818 )

gastric polyps ( J:78818 )

abnormal digestive system physiology ( J:78818 )

• at 43 weeks, mice present with gastrointestinal obstruction

intestinal obstruction ( J:78818 )

neoplasm

increased tumor incidence ( J:78818 , J:131037 )

• one animal exhibited a benign serous cyadenoma of the pancreas, and 2 showed asymptomatic benign uterine epithelial tumors, but no other neoplasms were observed in mutants (J:78818)

• mice have reduced cancer-free survival (28.6 weeks) relative to wild-type (>40 weeks) (J:131037)

• mutants are sensitized to squamous cell carcinoma compared to wild-type (J:131037)

increased incidence of tumors by chemical induction ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA (to promote development of lymphomas, sarcomas and lung adenomas) develop invasive skin and lung cancers not seen in wild-type mice

increased hamartoma incidence ( J:78818 )

• polyps present as mucosal hamartomas without dysplastic or adenomatous changes

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:131037 )

• 5-7 day-old mice treated with one dose of DMBA (to promote development of lymphomas, sarcomas and lung adenomas) develop invasive skin and lung cancers not seen in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:78818 , J:131037