Phenotypes Associated with This Genotype

Genotype
MGI:3814579

• Allelic Composition: Kmt2a^tm1Saam/Kmt2a⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:140628 )

• following pIpC treatment 14 of 22 mice developed acute leukemia

• median latency for leukemia development was 131 days

• infiltration of the bone marrow, spleen and liver with immature hematopoietic cells is seen in moribund mice

• mice may develop either acute myeloid leukemia or acute lymphoblastic leukemia

• gene expression profiles in mice with acute lymphoblastic leukemia recapitulate gene expression profiles seen in human acute lymphoid leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:140628
acute myeloid leukemia		DOID:9119	OMIM:601626	J:140628