Phenotypes Associated with This Genotype

Genotype
MGI:3814580

• Allelic Composition: Tg(MT1A-Dyrk1a)33Xest/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:71821 )

• mice exhibit learning in a Morris water maze compared to wild-type mice with longer escape latencies in the first acquisition sessions

• mice are not effective at discriminating previously trained quadrants

abnormal spatial reference memory ( J:71821 )

• in a repeated acquisition version of the Morris water maze, mice display increased escape latencies and distance traveled compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:71821