Phenotypes Associated with This Genotype

Genotype
MGI:3814728

• Allelic Composition: Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
• Genetic Background: C.129-Cx3cr1^tm1Zm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:127548 )

• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice

• however, dark raised mice exhibit reduced numbers of subretinal microglial cells in the retina

abnormal retina photoreceptor layer morphology ( J:127548 )

• the retinal photoreceptor layer is thin at 2 months and degenerated at 4 months of age

• however, dark raised mice do not exhibit thinning or degeneration

retina degeneration ( J:127548 )

• mice exhibit degeneration of the outer retina

• however, dark raised mice do not exhibit degeneration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration 12		DOID:0110024	OMIM:613784	J:127548