Phenotypes Associated with This Genotype

Genotype
MGI:3814729

• Allelic Composition: Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

choroidal neovascularization ( J:127548 )

• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice

abnormal retina morphology ( J:127548 )

• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice

thin retina outer nuclear layer ( J:127548 )

• at 12 months, mice exhibit a 30% reduction in the thickness of the retinal outer nuclear layer compared to in wild-type mice

abnormal retina photoreceptor layer morphology ( J:127548 )

• at 18 months, the thickness of the retinal photoreceptor cell layer is reduced to 40% of wild-type

• following laser injury, mice exhibit increased degeneration compared to untreated homozygotes or similarly treated wild-type mice

• however, mice do not exhibit increased degeneration following laser injuries at distances of 300 and 400 um from laser impact

retina degeneration ( J:127548 )

• at 18 months

retina deposits ( J:127548 )

• mice exhibit an accumulation of yellow, lipid-bloated subretinal microglial cells in the deep layer of the retina with age that is not observed in wild-type mice

cardiovascular system

choroidal neovascularization ( J:127548 )

• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration 12		DOID:0110024	OMIM:613784	J:127548