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Phenotypes Associated with This Genotype
Genotype
MGI:3814906
Allelic
Composition		 Six3tm4(cre/ERT2)Gco/Six3+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six3tm4(cre/ERT2)Gco mutation (0 available); any Six3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
holoprosencephaly ( J:140315 )
• Background Sensitivity: 16% display a phenotype typical of holoprosencephaly after one backcross to C57BL/6
• Background Sensitivity: after two additional backcrosses to C57BL/6, 85% show a holoprosencephaly phenotype

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
holoprosencephaly 2 DOID:0110872 OMIM:157170
 J:140315

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory