Phenotypes Associated with This Genotype

Genotype
MGI:3814998

• Allelic Composition: Pde6g^tm1Goff/Pde6g^tm1Goff
• Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina photoreceptor layer morphology ( J:33048 )

• at 8 weeks of age, mice lack any photoreceptor layer

decreased retina photoreceptor cell number ( J:33048 )

• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas

disorganized photoreceptor outer segment ( J:33048 )

• at P10

photoreceptor outer segment degeneration ( J:33048 )

• most of the outer segment is lost by P13

abnormal eye electrophysiology ( J:33048 )

• mice exhibit diminished a and b wave components compared to wild type mice with a delay in the b wave implicit time

• diminished eye electrophysiological response worsens with age

nervous system

decreased retina photoreceptor cell number ( J:33048 )

• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas

disorganized photoreceptor outer segment ( J:33048 )

• at P10

photoreceptor outer segment degeneration ( J:33048 )

• most of the outer segment is lost by P13

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa		DOID:10584	OMIM:PS268000	J:33048