Phenotypes Associated with This Genotype

Genotype
MGI:3815023

• Allelic Composition: Fmr1^tm2Cgr/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:104445 )

♂ • at 72 weeks, male mice (106 to 123 CGG repeats) in an open field test travel shorter distances and enter the center circle fewer times than wild-type mice

♂ • however, activity and exploration levels are normal

abnormal learning/memory/conditioning ( J:104445 )

♂ • at 52 weeks, male mice (106 to 123 CGG repeats) in a Morris water maze exhibit impaired visual-spatial learning and memory compared to wild-type mice with increased escape latency and path length

impaired coordination ( J:104445 )

♂ • male mice (106 to 123 CGG repeats) exhibit decreased performance on a rotarod as they age unlike wild-type mice

♂ • at 52 and 72 weeks, male mice (106 to 123 CGG repeats) exhibit reduced latency to fall on a rotarod test compared to at 20 weeks of age

♂ • at 72 weeks, male mice (106 to 123 CGG repeats) exhibit a lower number of segments crossed on a stationary beam compared to wild-type mice

♂ • however, mice perform as wild-type mice in a gait test

decreased grip strength ( J:104445 )

♂ • at 52 weeks, male mice (106 to 123 CGG repeats) exhibit decreased latency to first fall in a wire suspension test and fall more often than wild-type mice

♂ • however, performance in a wire suspension test is normal at 20 and 72 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fragile X-associated tremor/ataxia syndrome		DOID:0050879	OMIM:300623	J:104445