Analysis Tools
mortality/aging
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• despite the delay in disease progression, lifespan is similar to transgenic mice wild type for Bbc3
|
nervous system
|
• gliosis and microglial activation in the spinal cord at 90 days of age are reduced compared to transgenic mice wild type for Bbc3
• however, by the end stage of the disease, gliosis and microglial activation are similar to transgenic mice wild type for Bbc3
|
|
• significant delay in motor neuron loss compared to transgenic mice wild type for Bbc3
• however, in older mice with end stage disease motor neuron loss in not different from transgenic mice wild type for Bbc3
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behavior/neurological
| N |
• unlike transgenic mice wild type for Bbc3, no decrease in stride length is seen even at 120 days of age
|
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• decline in paw grip endurance beginning at 98 days of age compared to 77 days of age in transgenic mice wild type for Bbc3
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growth/size/body
weight loss
(
J:130581
)
|
• body weight begins to significantly decrease at 105 days of age compared to 77 days of age in transgenic mice wild type for Bbc3
|
