Phenotypes Associated with This Genotype

Genotype
MGI:3815142

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased intraocular melanoma incidence ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

increased incidence of tumors by UV-induction ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

vision/eye

increased intraocular melanoma incidence ( J:140820 )

♂ • following exposure to UVA and UVB, 2 of 46 mice exhibit uveal melanoma

cataract ( J:140820 )

♂ • following exposure to UVA and UVB, only one mouse developed cataracts unlike Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-HRAS)60Lc mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
uveal melanoma		DOID:6039	OMIM:155720 OMIM:606660 OMIM:606661	J:140820