Phenotypes Associated with This Genotype

Genotype
MGI:3815302

• Allelic Composition: Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

nervous system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

hematopoietic system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:140907