Analysis Tools
nervous system
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• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus instead of the increase observed in wild-type mice
• however, neuronal circuits in the dentate gyrus are normal
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• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
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• following treatment with tamoxifen, mice exhibit ablation of newly forming neurons
• following treatment with tamoxifen, neuroblasts at the entry site of the rostral migratory stream exhibit markers of apoptosis
• 3 weeks following treatment with tamoxifen, mice exhibit ablation of newly formed neurons in the olfactory bulb that becomes more severe at 6 and 12 weeks of treatment
• following treatment with tamoxifen, mice exhibit a loss of granule cells in deep regions while superficial neurons are preserved
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• 3 weeks following treatment with tamoxifen, mice exhibit loss of granule neurons in the olfactory bulb
• following treatment with tamoxifen, mice exhibit decreased granule cell density in the dentate gyrus compared to in wild-type mice
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behavior/neurological
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• despite ablation of olfactory neurons, mice exhibit normal behavior towards wild-type mice and normal odor-associated memory
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• tamoxifen treated mice exhibit reduced freezing responses compared to wild-type mice
• however, cue conditioning is normal
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• in a Barnes maze spatial memory test, tamoxifen treated mice exhibit impaired retention of spatial memory compared to wild-type mice
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