Phenotypes Associated with This Genotype

Genotype
MGI:3817455

• Allelic Composition: Arid4a^tm1Alb/Arid4a^tm1Alb; Arid4b^tm1Alb/Arid4b⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141004 )

• mice exhibit increased mortality at 7 months of age

postnatal lethality ( J:141004 )

• 25% of mice die before 1 month

hematopoietic system

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

abnormal definitive hematopoiesis ( J:141004 )

abnormal common myeloid progenitor cell morphology ( J:141004 )

• increased in the spleen and bone marrow

abnormal leukopoiesis ( J:141004 )

• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice

extramedullary hematopoiesis ( J:141004 )

abnormal myeloblast morphology/development ( J:141004 )

• the peripheral blood of mice with acute myeloid leukemia (AML) contains more than 20% atypical cells with morphology consistent with blasts and immature myeloid precursors unlike in wild-type mice

decreased erythrocyte cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased erythrocyte cell number ( J:141004 )

• the spleen of mice of mice with acute myeloid leukemia (AML)

thrombocytopenia ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased lymphocyte cell number ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased B cell number ( J:141004 )

• the bone marrow and spleens of mice with acute myeloid leukemia (AML)

decreased T cell number ( J:141004 )

• the spleen of mice with acute myeloid leukemia (AML)

increased leukocyte cell number ( J:141004 )

• the bone marrow spleens of mice with acute myeloid leukemia (AML)

increased neutrophil cell number ( J:141004 )

• in mice with acute myeloid leukemia (AML)

increased T cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased monocyte cell number ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit monocytosis

increased hematopoietic stem cell number ( J:141004 )

• hematopoietic stem cell populations are expanded in the bone marrow and spleen compared to in wild-type mice and Arid4a^tm1Alb homozygotes

hemophagocytosis ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

neoplasm

increased leukemia incidence ( J:141004 )

• 83% of mice develop acute myeloid leukemia between 7 and 15 months of age

increased sarcoma incidence ( J:141004 )

• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

liver/biliary system

enlarged liver ( J:141004 )

• in mice with acute myeloid leukemia (AML)

skeleton

abnormal bone marrow morphology ( J:141004 )

• mice that exhibit acute myeloid leukemia (AML) also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice

• the bone marrow of mice with AML increase in granulocytes, monocytes, T lymphoid cells, and erythroid cells and a decrease in B lymphoid cells compared to in wild-type mice

• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice and Arid4a^tm1Alb homozygotes

respiratory system

abnormal lung vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

cardiovascular system

abnormal blood vessel morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung, kidney and lymph node blood vessels indicative of leukemic involvement

abnormal kidney vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

abnormal lung vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

renal/urinary system

abnormal kidney vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

growth/size/body

decreased body weight ( J:141004 )

• at 7 weeks of age, mice weigh 30% less than wild-type mice

enlarged liver ( J:141004 )

• in mice with acute myeloid leukemia (AML)

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

immune system

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

abnormal leukopoiesis ( J:141004 )

• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice

decreased lymphocyte cell number ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased B cell number ( J:141004 )

• the bone marrow and spleens of mice with acute myeloid leukemia (AML)

decreased T cell number ( J:141004 )

• the spleen of mice with acute myeloid leukemia (AML)

increased leukocyte cell number ( J:141004 )

• the bone marrow spleens of mice with acute myeloid leukemia (AML)

increased neutrophil cell number ( J:141004 )

• in mice with acute myeloid leukemia (AML)

increased T cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased monocyte cell number ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit monocytosis

hemophagocytosis ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:141004