Phenotypes Associated with This Genotype

Genotype
MGI:3817462

• Allelic Composition: Mecp2^tm1Bird/Y
• Genetic Background: (129S6.129P2-Mecp2^tm1Bird x FVB/N)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:135825 )

♂N • no early mortality is observed in contrast to Mecp2-null animals

behavior/neurological

behavior/neurological phenotype ( J:135825 )

♂N • Background Sensitivity: no overt abnormalities are observed; mutants do not exhibit impaired coordination in a variety of tests measured

♂N • mice do not show overt abnormalities like tremor or limb grasping

abnormal contextual conditioning behavior ( J:135825 )

♂ • percentage of time spent freezing is elevated relative to wild-type when placed back into the conditioning chamber

abnormal cued conditioning behavior ( J:135825 )

♂ • percentage of time spent freezing is elevated relative to wild-type when re-exposure to a previously experienced cue

decreased anxiety-related response ( J:135825 )

♂ • mice show decrease anxiety-related behavior in open field assays than wild-type mice

increased vertical activity ( J:135825 )

♂ • increased number of vertical explorations is observed compared to wild-type; this is indicative of reduced anxiety

abnormal touch/ nociception ( J:135825 )

♂ • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity

abnormal social investigation ( J:135825 )

♂ • mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system

decreased prepulse inhibition ( J:135825 )

♂ • mice show decreased prepulse inhibition compared to wild-type

respiratory system

abnormal breathing pattern ( J:135825 )

♂ • at 4 months, respiratory pattern is qualitatively different than in wild-type; coefficient of variability of the respiratory rhythm is higher than in wild-type

apnea ( J:135825 )

♂ • increase in apnea incidence (39.5/hour) is observed compared to wild-type (5.8/hour)

growth/size/body

growth/size/body region phenotype ( J:135825 )

♂N • Background Sensitivity: no size difference is detected relative to wild-type, unlike mice on the C57BL/6 background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:135825