Analysis Tools
skeleton
| N |
• despite the increased osteoclastic potential of bone marrow cells, no abnormal bone phenotype is observed in histotomorphometric evaluation of vertebral bones from mice up to 1 year in age
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• unfractionated bone marrow cells produce more osteoclasts in vitro when cultured with various differentiation factors
• maximal numbers of osteoclasts form from bone marrow cultures after 6 days in the presence of RANKL, while maximal numbers are not reached until 9 days in wild-type cultures
• highly purified osteoclast precursors form increased numbers of osteoclasts in response to TNF and RANKL compared to wild-type
• highest number of osteoclasts develop when mutant precursors are cultured with mutant bone marrow stromal cells
• mutant bone marrow stromal cells double the differentiation rate in vitro of wild-type osteoclast precursors into osteoclasts
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• a 1.5-fold increase in bone resorption is observed when osteoclasts are treated with RANKL (50 ng/ml) and cultured on dentin
• however, the area resorbed per osteoclasts is not different between mutant and wild-type cells
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hematopoietic system
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• unfractionated bone marrow cells produce more osteoclasts in vitro when cultured with various differentiation factors
• maximal numbers of osteoclasts form from bone marrow cultures after 6 days in the presence of RANKL, while maximal numbers are not reached until 9 days in wild-type cultures
• highly purified osteoclast precursors form increased numbers of osteoclasts in response to TNF and RANKL compared to wild-type
• highest number of osteoclasts develop when mutant precursors are cultured with mutant bone marrow stromal cells
• mutant bone marrow stromal cells double the differentiation rate in vitro of wild-type osteoclast precursors into osteoclasts
|
|
• a 1.5-fold increase in bone resorption is observed when osteoclasts are treated with RANKL (50 ng/ml) and cultured on dentin
• however, the area resorbed per osteoclasts is not different between mutant and wild-type cells
|
immune system
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• unfractionated bone marrow cells produce more osteoclasts in vitro when cultured with various differentiation factors
• maximal numbers of osteoclasts form from bone marrow cultures after 6 days in the presence of RANKL, while maximal numbers are not reached until 9 days in wild-type cultures
• highly purified osteoclast precursors form increased numbers of osteoclasts in response to TNF and RANKL compared to wild-type
• highest number of osteoclasts develop when mutant precursors are cultured with mutant bone marrow stromal cells
• mutant bone marrow stromal cells double the differentiation rate in vitro of wild-type osteoclast precursors into osteoclasts
|
|
• a 1.5-fold increase in bone resorption is observed when osteoclasts are treated with RANKL (50 ng/ml) and cultured on dentin
• however, the area resorbed per osteoclasts is not different between mutant and wild-type cells
|
cellular
|
• unfractionated bone marrow cells produce more osteoclasts in vitro when cultured with various differentiation factors
• maximal numbers of osteoclasts form from bone marrow cultures after 6 days in the presence of RANKL, while maximal numbers are not reached until 9 days in wild-type cultures
• highly purified osteoclast precursors form increased numbers of osteoclasts in response to TNF and RANKL compared to wild-type
• highest number of osteoclasts develop when mutant precursors are cultured with mutant bone marrow stromal cells
• mutant bone marrow stromal cells double the differentiation rate in vitro of wild-type osteoclast precursors into osteoclasts
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | Paget's disease of bone | DOID:5408 |
OMIM:PS167250 |
J:141179 |
