Phenotypes Associated with This Genotype

Genotype
MGI:3817777

cx23

• Allelic Composition: Ins2^Akita/Ins2⁺; Prf1^tm1Sdz/Prf1^tm1Sdz; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: NOD.Cg-Rag1^tm1Mom Ins2^Akita Prf1^tm1Sdz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:138005 )

• islets exhibit progressively altered morphology

• insulin level is lower compared to Ins2-wild-type mice at 50 days of age and continues to diminish with age

hematopoietic system

increased erythrocyte cell number ( J:138005 )

• erythrocyte/erythocyte lineages (Ter 119+) are increased as compared to NOD controls

increased granulocyte number ( J:138005 )

• percentage of granulocytes is elevated compared to NOD/Lt

absent mature B cells ( J:138005 )

• lacking in mutant animals

absent T cells ( J:138005 )

• mature T cells are absent in mutant animals

increased macrophage cell number ( J:138005 )

• percentage of granulocytes is elevated

increased monocyte cell number ( J:138005 )

• percentage of granulocytes is elevated

immune system

increased granulocyte number ( J:138005 )

• percentage of granulocytes is elevated compared to NOD/Lt

absent mature B cells ( J:138005 )

• lacking in mutant animals

absent T cells ( J:138005 )

• mature T cells are absent in mutant animals

increased macrophage cell number ( J:138005 )

• percentage of granulocytes is elevated

increased monocyte cell number ( J:138005 )

• percentage of granulocytes is elevated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:138005 )

N • spontaneously hyperglycemic mice are restored to euglycemia after receiving islet transplants at a dose of 4000 islet equivalents (IEQ) and remain euglycemic for the length of observation; at levels of 2000 and 3000 IEQ, mice display a drop in blood sugar, but eventually return to hyperglycemic status

abnormal glucose homeostasis ( J:138005 )

• glucose regulation is impaired as early as 3 weeks of age in nearly all mice

hyperglycemia ( J:138005 )

• male mice show greater susceptibility to develop hyperglycemia than females