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Phenotypes Associated with This Genotype
Genotype
MGI:3818331
cx14
Allelic
Composition		 Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:97824 )
N
• the numbers of intraepithelial lymphocytes in the small intestine is normal
increased T cell number ( J:97824 )
• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
decreased IgA level ( J:97824 )
• in the serum compared to wild-type mice

hematopoietic system
increased T cell number ( J:97824 )
• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrdtm1Mom homozygotes
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
decreased IgA level ( J:97824 )
• in the serum compared to wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory