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Phenotypes Associated with This Genotype
Genotype
MGI:3818332
cx15
Allelic
Composition		 Pigrtm1Ohw/Pigrtm1Ohw
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Ohw mutation (0 available); any Pigr mutation (60 available)
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (97 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:97824 )
N
• unlike in Pigrtm1Ohw homozygotes, the numbers of intraepithelial lymphocytes in the small intestine is normal
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
increased IgA level ( J:97824 )
• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes

hematopoietic system
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
increased IgA level ( J:97824 )
• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory