Phenotypes for Coro1a MGI:3818532 MGI Mouse

immune system

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

• CD4⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• CD8⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• in vitro transwell assays demonstrate migration defects in thymic CD4⁺ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12

• similar defects are observed in the migratory response of CD4⁺CD8⁺ T cells to CXCL12 and of splenic CD4⁺ T cells to CCL21

hematopoietic system

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

• CD4⁺ T cell numbers in the periphery are significantly decreased about 5-fold

• CD8⁺ T cell numbers in the periphery are significantly decreased about 5-fold

abnormal T cell physiology ( J:141431 )

• in vitro transwell assays demonstrate migration defects in thymic CD4⁺ T cells' response to sphingosine 1-phosphate, CCL21, and CXCL12

• similar defects are observed in the migratory response of CD4⁺CD8⁺ T cells to CXCL12 and of splenic CD4⁺ T cells to CCL21

endocrine/exocrine glands

decreased thymocyte number ( J:141431 )

• the percentage of mature (CD69^loCD62L^hi) single-positive thymocytes is decreased in these mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive		DOID:0090014	OMIM:608971	J:141431

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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