Phenotypes Associated with This Genotype

Genotype
MGI:3818698

• Allelic Composition: Taar1^tm1Tdw/Taar1^tm1Tdw
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:141501 )

N • no significant differences in anxiety or overall activity levels were found

enhanced behavioral response to addictive substance ( J:141501 )

• increase in the sensitivity to psychomotor-stimulating effects of amphetamine compared to wild-type mice

• baseline activity levels are similar to wild-type mice

nervous system

abnormal prepulse inhibition ( J:141501 )

• overall lower percent prepulse inhibition of the acoustic startle response compared to wild-type controls

• baseline startle amplitude is similar to wild-type

homeostasis/metabolism

increased dopamine level ( J:141501 )

• increased striatal levels following exposure to amphetamine

• basal levels of dopamine are similar to wild-type mice

abnormal noradrenaline level ( J:141501 )

• increased striatal levels following exposure to amphetamine

• basal levels of norepinephrine are similar to wild-type mice

increased physiological sensitivity to xenobiotic ( J:141501 )

• amphetamine induced increases in dopamine and norepinephrine are enhanced compared to wild-type mice

• basal levels of dopamine and norepinephrine are similar to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:141501