Phenotypes Associated with This Genotype

Genotype
MGI:3818741

• Allelic Composition: Tg(Ins-Igf2)1Fbos/0
• Genetic Background: involves: C57BL/6 * C57BLKs/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:141527 )

increased circulating insulin level ( J:141527 )

increased circulating free fatty acids level ( J:141527 )

• slight

increased circulating triglyceride level ( J:141527 )

• slight

insulin resistance ( J:141527 )

• Background Sensitivity: mice exhibit insulin resistance that is more severe than on a C57BL/6 SJL mixed background

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:141527 )

• islet cells are larger, more elongated and more irregularly shared than in wild-type mice

disorganized pancreatic islets ( J:141527 )

• glucagon-producing cells are scattered throughout the islet core unlike in wild-type mice

growth/size/body

obese ( J:141527 )

• at 12 months of age, mice exhibit a 60% increase in body weight compared to a 27% increased in wild-type mice

liver/biliary system

hepatic steatosis ( J:141527 )

• at 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus 2		DOID:0110741	OMIM:125852	J:141527