Phenotypes Associated with This Genotype

Genotype
MGI:3818748

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Trp53^tm1Brd/Trp53^tm1Brd; Xrcc5^tm1Dbr/Xrcc5^tm1Dbr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141515 )

• median lifespan is 14 weeks compared to 7 weeks in Trp53^tm1Brd Xrcc5^tm1Dbr

• maximum lifespan is 20 weeks compared to 16 weeks in Trp53^tm1Brd Xrcc5^tm1Dbr

neoplasm

increased stomach tumor incidence ( J:141515 )

• one mouse developed a stomach neoplasm

increased T cell derived lymphoma incidence ( J:141515 )

• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

increased medulloblastoma incidence ( J:141515 )

• mice that exhibit vertigo develop medulloblastoma

• 66.7% of mice exhibit medulloblastoma at the time of morbidity

increased sarcoma incidence ( J:141515 )

• in one mouse

respiratory system

respiratory distress ( J:141515 )

• one-fifth of mice exhibit labored breathing prior to death compared to two-thirds of Rag1^tm1Mom Trp53^tm1Brd

behavior/neurological

impaired balance ( J:141515 )

• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism

dehydration ( J:141515 )

• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:141515 )

• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

nervous system

increased medulloblastoma incidence ( J:141515 )

• mice that exhibit vertigo develop medulloblastoma

• 66.7% of mice exhibit medulloblastoma at the time of morbidity

digestive/alimentary system

increased stomach tumor incidence ( J:141515 )

• one mouse developed a stomach neoplasm

immune system

increased T cell derived lymphoma incidence ( J:141515 )

• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

hematopoietic system

increased T cell derived lymphoma incidence ( J:141515 )

• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:141515