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Phenotypes Associated with This Genotype
Genotype
MGI:3819384
cn5
Allelic
Composition
Smarcb1tm1Sho/Smarcb1tm2Sho
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcb1tm1Sho mutation (0 available); any Smarcb1 mutation (23 available)
Smarcb1tm2Sho mutation (1 available); any Smarcb1 mutation (23 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 90% mortality between 1 and 3 weeks after injection with polyI/polyC
• remaining mice die over the next 4 weeks

hematopoietic system
• deficiency of hematopoietic cells in the bone marrow
• mice are ill and profoundly pancytopenic by weeks 1-2 after polyI/polyC injection
• some mice develop mild or transient pancytopenia but still experience sudden death

cardiovascular system
• extensive skin bruising

digestive/alimentary system


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory