Phenotypes Associated with This Genotype

Genotype
MGI:3820200

• Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

malocclusion ( J:102709 )

• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth

periorbital fullness ( J:102709 )

• periorbital fullness is a characteristic of these mice

asymmetric snout ( J:102709 )

• 20% of mice have a twisted snout

• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees

short snout ( J:102709 )

• mice have a characteristically short snout

growth/size/body

malocclusion ( J:102709 )

• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth

periorbital fullness ( J:102709 )

• periorbital fullness is a characteristic of these mice

asymmetric snout ( J:102709 )

• 20% of mice have a twisted snout

• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees

short snout ( J:102709 )

• mice have a characteristically short snout

decreased body weight ( J:102709 )

• body weight of 1- and 2- month old mice that have properly aligned jaws is a few grams less than controls

• weights of mice with misaligned jaws is dramatically less

skeleton

malocclusion ( J:102709 )

• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth

behavior/neurological

abnormal mastication ( J:102709 )

• the 20% of mice with malocclusions are unable to manipulate hard food pellets

limb grasping ( J:102709 )

• mice display an abnormal clasping or kicking behavior upon lifting

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:102709