Analysis Tools
reproductive system
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• at 12 weeks of age, increased stromal cell proliferation is noted in the center of the mutant ovary
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• while normal-appearing primary follicles and some small antral follicles are present, only a few large antral follicles and corpora lutea are observed
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• at 6-12 weeks of age, female homozygotes show limited follicular development beyond the early antral follicle stage
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small ovary
(
J:64299
)
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• homozygous mutant ovaries are often smaller than wild-type ovaries
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• 5 of 16 female homozygotes failed to become pregnant over a 2-6 month period
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• female homozygotes survive to adulthood and appear to show normal sexual differentiation but are subfertile
• whereas breeding of 5 female heterozygotes with male heterozygotes over a 6 month period produced an average of 1.0 litter/month, only 11 of 16 female homozygotes became pregnant over a 2-6 month period averaging 0.23 litters/month
• however, mutant and control females were shown to produce a similar number of eggs upon pharmacological superovulation
• in contrast to females, male homozygotes are fertile with normal testicular morphology
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• over a 2-6 month period, female homozygotes produced a significantly decreased average litter size relative to female heterozygotes (2.7 vs 8.6 offspring/litter, respectively)
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endocrine/exocrine glands
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• increase in periglandular fibrosis from 10 to 50 weeks of age
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• decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age
• accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age
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• at 12 weeks of age, increased stromal cell proliferation is noted in the center of the mutant ovary
|
|
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• while normal-appearing primary follicles and some small antral follicles are present, only a few large antral follicles and corpora lutea are observed
|
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• at 6-12 weeks of age, female homozygotes show limited follicular development beyond the early antral follicle stage
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small ovary
(
J:64299
)
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• homozygous mutant ovaries are often smaller than wild-type ovaries
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• increase in apoptosis within the meibomian glands at 50 weeks of age
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• increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age
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homeostasis/metabolism
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• adult female homozygotes exhibit suppressed serum FSH levels relative to control females (38.5 +/- 3.1 ng/ml vs 105.0 +/- 17.3 ng/ml, respectively), as shown by RIA analysis
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• adult female homozygotes exhibit suppressed serum LH levels relative to control females (17.4 +/- 3.0 ng/ml vs 57.8 +/- 17.7 ng/ml, respectively), as shown by RIA analysis
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• increase in the mean serum IL-6 concentration from 10 to 50 weeks of age
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• increase in serum TNF-alpha levels from 10 weeks of age
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cellular
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• mitochondrial swelling, disorientation, shortening, and disorganization of cristae are seen in 80% of 50 week old mice compared to 40% of wild-type mice at this age
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• in 50 week old mice
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• in 50 week old mice
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• mice exhibit changes in oxidative stress markers in the meibomian glands
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immune system
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• increase in the mean serum IL-6 concentration from 10 to 50 weeks of age
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• increase in serum TNF-alpha levels from 10 weeks of age
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• increase in tear IL-6 concentration from 10 to 50 weeks of age
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• increase in mean tear TNF-alpha concentration from 10 to 50 weeks of age
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blepharitis
(
J:219024
)
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• eyelid inflammation
• mice exhibit changes in tear, serum and eye lid tissue inflammatory markers
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• increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age
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integument
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• increase in periglandular fibrosis from 10 to 50 weeks of age
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• decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age
• accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age
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• increase in apoptosis within the meibomian glands at 50 weeks of age
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• increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age
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vision/eye
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• increase in periglandular fibrosis from 10 to 50 weeks of age
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• decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age
• accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age
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blepharitis
(
J:219024
)
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• eyelid inflammation
• mice exhibit changes in tear, serum and eye lid tissue inflammatory markers
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• increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age
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• mean corneal vital staining score is worse at 10 and 50 weeks of age indicating ocular surface epithelial cell damage
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• lower tear break up time is seen at 50 weeks of age compared to wild-type mice indicating decreased tear stability
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• mean weight adjusted aqueous tear production is lower at 10 and 50 weeks of age and mice show a significant decrease in tear quantity from 10 to 50 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dry eye syndrome | DOID:10140 | J:219024 | ||
