Phenotypes Associated with This Genotype

Genotype
MGI:3821602

• Allelic Composition: Hbb-b1^MommeD7/Hbb-b1^MommeD7
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:190446 )

• die by E18.5

postnatal lethality ( J:142335 )

• semidominant homozygous lethal

• never seen at weaning

• death occurs within a few days of birth

hematopoietic system

decreased erythrocyte cell number ( J:142335 )

• at E17.5

integument

pallor ( J:142335 , J:190446 )

• about 1/4 of mice are pale in color at E17.5 (J:142335)

• progressive pallor starting at E16.5 (J:190446)

liver/biliary system

abnormal liver morphology ( J:190446 )

• fetal livers contain poorly hemoglobinized erythroblasts with inclusions

liver hypoplasia ( J:190446 )

• fewer fetal liver cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:190446