Phenotypes Associated with This Genotype

Genotype
MGI:3822318

• Allelic Composition: Lepr^tm2Yli/Lepr^tm2Yli
• Genetic Background: B6.129-Lepr^tm2Yli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:142218 )

• increase in body weight is less than that in Lepr ^db mice

obese ( J:142218 )

• early onset obesity beginning about 4 weeks of age

• rate of weight gain begins to decline after 6 weeks of age compared to mice homozygous for Lepr ^db

increased body length ( J:142218 )

• increase in snout to anus length compared to wild-type mice and mice homozygous for Lepr ^db

adipose tissue

increased percent body fat/body weight ( J:142218 )

• fat content is increased compared to wild-type mice but decreased compared to mice homozygous for Lepr ^tm1Yli or Lepr ^db

• at 8 weeks and 28 weeks of age body fat content in males is 7 fold and 2 fold higher, respectively, compared to wild-type controls

homeostasis/metabolism

impaired adaptive thermogenesis ( J:142218 )

• thermoregulation in response to cold exposure is slightly but significantly impaired compared to wild-type controls but improved compared to mice homozygous for Lepr ^db

abnormal circulating glucose level ( J:142218 )

• fasting serum glucose levels are significantly lower than those in mice homozygous for Lepr ^db

increased circulating insulin level ( J:142218 )

• increased levels relative to wild-type controls but decreased levels compared to mice homozygous for Lepr ^tm1Yli or Lepr ^db

increased circulating leptin level ( J:142218 )

• relatively modest hyperleptinemia compared to mice homozygous for Lepr ^db

abnormal body temperature ( J:142218 )

• increased compared to mice homozygous for Lepr ^db but not significantly different from wild-type controls

abnormal oxygen consumption ( J:142218 )

• oxygen consumption normalized to lean mass is similar to wild-type controls but decreased relative to mice homozygous for Lepr ^db

• oxygen consumption normalized to metabolic size is decreased by about 20% compared to wild-type controls but is still higher than in mice homozygous for Lepr ^db

impaired glucose tolerance ( J:142218 )

• impaired compared to wild-type controls but not as bad as in mice homozygous for Lepr ^tm1Yli or Lepr ^db

insulin resistance ( J:142218 )

• resistant compared to wild-type controls but more sensitive compared to mice homozygous for Lepr ^tm1Yli or Lepr ^db

behavior/neurological

polyphagia ( J:142218 )

• hyperphagia is less pronounced compared to mice homozygous for Lepr ^db

decreased locomotor activity ( J:142218 )

• activity levels in both dark and light cycles are decreased compared to wild -type controls but increased compared to mice homozygous for Lepr ^db

reproductive system

reduced female fertility ( J:142218 )

♀ • fertility is about 40% that of wild-type controls

male infertility ( J:142218 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:142218