Phenotypes Associated with This Genotype

Genotype
MGI:3822320

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(S100b-v-erbB)4496Waw/0
• Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82649 )

• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

neoplasm

increased glioma incidence ( J:82649 )

• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice

increased oligodendroglioma incidence ( J:82649 )

• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

decreased tumor latency ( J:82649 )

• mice exhibit decreased latency of glioma development compared to Tg(S100b-v-erbB)4496Waw mice

nervous system

increased glioma incidence ( J:82649 )

• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice

increased oligodendroglioma incidence ( J:82649 )

• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligodendroglioma		DOID:3181		J:82649