Phenotypes Associated with This Genotype

Genotype
MGI:3822323

• Allelic Composition: Tg(S100b-v-erbB)4496Waw/0; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82649 )

• 80% of mice die within 6 months of high grade oligodendroglioma

neoplasm

increased glioma incidence ( J:82649 )

• mice develop gliomas as in Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele

increased oligodendroglioma incidence ( J:82649 )

• 80% of mice die within 6 months of high grade oligodendroglioma

nervous system

increased glioma incidence ( J:82649 )

• mice develop gliomas as in Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele

increased oligodendroglioma incidence ( J:82649 )

• 80% of mice die within 6 months of high grade oligodendroglioma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligodendroglioma		DOID:3181		J:82649