Phenotypes Associated with This Genotype

Genotype
MGI:3822998

hm1

• Allelic Composition: Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased corpora lutea number ( J:142042 )

♀ • females exhibit an abnormally large number of corpora lutea

increased tertiary ovarian follicle number ( J:142042 )

♀ • females exhibit an abnormally large number of late stage antral follicles

enlarged ovary ( J:142042 )

♀

hemorrhagic ovary cyst ( J:142042 )

♀ • occasionally develop hemorrhagic cysts

enlarged uterus ( J:142042 )

♀

long gestation period ( J:142042 )

♀ • the few observed pregnancies last longer, between 21 and 23 days instead of 19 days, however pups are either born dead or mothers show declining health and were sacrificed

prolonged estrous cycle ( J:142042 )

♀ • length of estrus cycle is protracted, lasting up to 4 days instead of the normal 13 hours

reduced female fertility ( J:142042 )

♀

decreased litter size ( J:142042 )

• smaller litter size (2.8 vs 9.3 in wild type)

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

increased corpora lutea number ( J:142042 )

♀ • females exhibit an abnormally large number of corpora lutea

increased tertiary ovarian follicle number ( J:142042 )

♀ • females exhibit an abnormally large number of late stage antral follicles

enlarged ovary ( J:142042 )

♀

hemorrhagic ovary cyst ( J:142042 )

♀ • occasionally develop hemorrhagic cysts

growth/size/body

enlarged ovary ( J:142042 )

♀

hemorrhagic ovary cyst ( J:142042 )

♀ • occasionally develop hemorrhagic cysts