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Phenotypes Associated with This Genotype
Genotype
MGI:3823039
cn2
Allelic
Composition
Pdgfratm8Sor/Pdgfratm8Sor
Pdgfrbtm11Sor/Pdgfrbtm11Sor
Tg(Nr5a1-cre)2Klp/0
Genetic
Background
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm8Sor mutation (1 available); any Pdgfra mutation (87 available)
Pdgfrbtm11Sor mutation (1 available); any Pdgfrb mutation (87 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few mutants are recovered after birth, however mutants are recovered at E18.5, indicating perinatal lethality

endocrine/exocrine glands
• testes are frequently hemorrhagic at E18.5
• reduction in steroid-producing cells in the adrenal glands at E18.5
• reduction in adrenal cortex
• small adrenal glands are seen just before birth (E18.5)
• reduction in steroid-producing cells in the testis at E18.5
• small testes at E18.5

cardiovascular system
• testes are frequently hemorrhagic at E18.5

reproductive system
• testes are frequently hemorrhagic at E18.5
• reduction in steroid-producing cells in the testis at E18.5
• small testes at E18.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory