Phenotypes Associated with This Genotype

Genotype
MGI:3828268

cn1

• Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad; Foxn1^tm3(cre)Nrm/Foxn1⁺
• Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus cell ratio ( J:143472 )

• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4^tm1Frad homozygous control mice

• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice

• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice

decreased thymocyte number ( J:143472 )

• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4^tm1Frad homozygous control mice

increased immature B cell number ( J:143472 )

• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4^tm1Frad homozygous control mice

abnormal T cell differentiation ( J:143472 )

• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4^tm1Frad homozygous control mice

decreased double-positive T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of double positive T cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus

• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4^tm1Frad homozygous in control mice

decreased CD8-positive, alpha-beta T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus

• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4^tm1Frad homozygous control mice

hematopoietic system

abnormal thymus cell ratio ( J:143472 )

• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4^tm1Frad homozygous control mice

• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice

• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice

decreased thymocyte number ( J:143472 )

• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4^tm1Frad homozygous control mice

increased immature B cell number ( J:143472 )

• the absolute numbers of immature B cells in the thymus are increased 340-fold compared to in Dll4^tm1Frad homozygous control mice

abnormal T cell differentiation ( J:143472 )

• T cells differentiated in the thymus is nearly completely blocked unlike in Dll4^tm1Frad homozygous control mice

decreased double-positive T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of double positive T cells in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of CD4+ T cells in the thymus

• absolute numbers of CD4+ T cells is reduced 180- to 3000-fold compared to Dll4^tm1Frad homozygous in control mice

decreased CD8-positive, alpha-beta T cell number ( J:143472 )

• flow cytometry indicates a near complete loss of CD8+ T cells in the thymus

• absolute numbers of CD8+ T cells is reduced 180- to 3000-fold compared to in Dll4^tm1Frad homozygous control mice

endocrine/exocrine glands

abnormal thymus cell ratio ( J:143472 )

• absolute numbers of double negative cells in the thymus is increased 2-fold compared to in Dll4^tm1Frad homozygous control mice

• only CD4+CD25- DN1 cells are present and these DN cells are B220+ unlike in control mice

• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in control mice

decreased thymocyte number ( J:143472 )

• thymi exhibit a 14-fold reduction in the number of thymocytes compared to in Dll4^tm1Frad homozygous control mice