Phenotypes Associated with This Genotype

Genotype
MGI:3829382

• Allelic Composition: Lbr^ic-J/Lbr^ic-J
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:143838 )

• by 9 days of age

immune system

abnormal neutrophil differentiation ( J:143838 )

• Pelger-Huet anomaly by 9 days of age

abnormal spleen morphology ( J:143838 )

• chromatin clumping in spleen cells seen by electron microscopy

skeleton

abnormal long bone epiphyseal plate morphology ( J:143838 )

• tibial growth plates are markedly disorganized

abnormal trabecular bone morphology ( J:143838 )

• immature trabecular bone with residual cartilage

limbs/digits/tail

syndactyly ( J:143838 )

hematopoietic system

abnormal neutrophil differentiation ( J:143838 )

• Pelger-Huet anomaly by 9 days of age

abnormal spleen morphology ( J:143838 )

• chromatin clumping in spleen cells seen by electron microscopy

integument

sparse hair ( J:143838 )

• by 9 days of age

dry skin ( J:143838 )

• ichthyosis by 9 days of age

scaly skin ( J:143838 )

• ichthyosis by 9 days of age

cellular

abnormal neutrophil differentiation ( J:143838 )

• Pelger-Huet anomaly by 9 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ichthyosis vulgaris		DOID:1702	OMIM:146700	J:143838
Pelger-Huet anomaly		DOID:9631	OMIM:169400	J:143838