Phenotypes Associated with This Genotype

Genotype
MGI:3829418

cx19

• Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf; Tg(Rorc-EGFP)1Ebe/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls

• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased

• numbers of Th17 gammadelta T cells are normal

immune system

abnormal effector T cell morphology ( J:137020 )

• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls

• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased

• numbers of Th17 gammadelta T cells are normal