Phenotypes Associated with This Genotype

Genotype
MGI:3829421

cx5

• Allelic Composition: Foxp3^sf/Foxp3^sf; Tg(Rorc-EGFP)1Ebe/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

♀ • mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts

immune system

abnormal effector T cell morphology ( J:137020 )

♀ • mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts