Phenotypes Associated with This Genotype

Genotype
MGI:3829438

cn4

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Tg(Cyp1a1-cre)1Dwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver weight ( J:143082 )

• in mice induced with beta-naphthoflavonein mice induced with beta-naphthoflavonein mice induced with beta-naphthoflavone

hepatic steatosis ( J:143082 )

• in mice induced with beta-naphthoflavone

increased hepatocellular carcinoma incidence ( J:143082 )

• in one mouse induced with beta-naphthoflavone

neoplasm

increased hepatocellular carcinoma incidence ( J:143082 )

• in one mouse induced with beta-naphthoflavone

increased lymphoma incidence ( J:143082 )

• in mice induced with beta-naphthoflavone

reproductive system

endometrium hyperplasia ( J:143082 )

♀ • mice induced with beta-naphthoflavone exhibit atypical endometrial hyperplasia

behavior/neurological

abnormal behavior ( J:143082 )

• in mice induced with beta-naphthoflavone leading to euthanasia

digestive/alimentary system

digestive/alimentary phenotype ( J:143082 )

N • mice induced with beta-naphthoflavone exhibit normal crypt-villus architecture and physiology

growth/size/body

increased liver weight ( J:143082 )

• in mice induced with beta-naphthoflavonein mice induced with beta-naphthoflavonein mice induced with beta-naphthoflavone