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Phenotypes Associated with This Genotype
Genotype
MGI:3829711
cx6
Allelic
Composition		 Il2rbtm1Mak/Il2rbtm1Mak
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129 * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rbtm1Mak mutation (5 available); any Il2rb mutation (45 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:142654 )
• Ncr(NKp46)+ NK1.1+ NK cells are essentially absent
• however, the NKp46+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected

hematopoietic system
decreased NK cell number ( J:142654 )
• Ncr(NKp46)+ NK1.1+ NK cells are essentially absent
• however, the NKp46+CD127+ NK1.1- subset of intestinal natural killer cells is unaffected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory