Phenotypes Associated with This Genotype

Genotype
MGI:3830477

• Allelic Composition: Qrfpr^tm1Lex/Qrfpr^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:144011 )

N • in the femur the trochlear groove, epiphysis, growth plate, primary and secondary spongiosa, trabeculae and cortical bone are all similar to wild type mice

abnormal intervertebral disk morphology ( J:144011 )

• disks occupy larger spaces

abnormal nucleus pulposus morphology ( J:144011 )

• wider

kyphosis ( J:144011 )

• seen in most females and a few males

abnormal vertebrae morphology ( J:144011 )

• end plates display a wider hypertrophic zone and mildly disrupted calcified zone

• branching of trabeculae within the primary spongiosa is reduced and the trabeculae appear slightly thinner compared to controls

• the number of tartrate-resistant acid phosphatase positive cells is reduced especially in the secondary spongiosa

abnormal lumbar vertebrae morphology ( J:144011 )

• decrease in trabecular volume and connective density that is more severe in females than in males

abnormal vertebrae development ( J:144011 )

• results suggest an early arrest of osteochondral bone formation and reduced bone remodeling in the secondary spongiosa

decreased bone mineral density ( J:144011 )

• following ovariectomy the decrease in bone mineral density is greater in homozygous females compared to wild-type controls

• most of the difference in the decrease is attributable to a greater decrease in the bone mineral density of the spine

abnormal trabecular bone morphology ( J:144011 )

• in the vertebrae branching of trabeculae within the primary spongiosa is reduced and the trabeculae appear slightly thinner compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
bone structure disease		DOID:0080010		J:144011