Phenotypes Associated with This Genotype

Genotype
MGI:3831163

cn6

• Allelic Composition: Foxa1^tm1Khk/Foxa1^tm1Khk; Foxa2^tm1Khk/Foxa2^tm1Khk; Tg(Pdx1-cre)6Cvw/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:143476 )

• mice die within 2 days of birth

endocrine/exocrine glands

abnormal pancreas morphology ( J:143476 )

• the spaces between the remaining ductal epithelia are filled with stromal tissue, including fibroblasts and smooth musce cells

decreased pancreatic beta cell number ( J:143476 )

• very few beta cells are present between E17.5 and P1

pancreatic islet hypoplasia ( J:143476 )

abnormal pancreas development ( J:143476 )

• at E13.5, pancreatic precursor cells fail to expand resulting in fewer than normal glucagon+ and amylase+ cells

• pancreatic development is arrested at the early pancreatic cord stage

pancreas hypoplasia ( J:143476 )

• the pancreas occupies 19% relative area compared to in wild-type mice

• the numbers of endocrine cells, exocrine cells, and total epithelial tissue is severely decreased compared to in wild-type mice with remaining cells exhibiting an almost exclusively ductal phenotype

exocrine pancreas hypoplasia ( J:143476 )

homeostasis/metabolism

hyperglycemia ( J:143476 )

digestive/alimentary system

exocrine pancreas hypoplasia ( J:143476 )