Phenotypes Associated with This Genotype

Genotype
MGI:3831195

• Allelic Composition: Tg(Pbsn-Ar*E231G)7353Ng/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:96117 )

♂ • at 1 year all males show primary prostate tumors with associated lymphocytic invasion

increased prostate gland adenocarcinoma incidence ( J:96117 )

♂ • tumors are adenocarcinomas

increased metastatic potential ( J:96117 )

• metastatic deposits are detected in lungs of all mice and 50 weeks

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:96117 )

♂ • epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks; lesions present as disorganized layers of epithelial cells in contrast to single regular layer observed in controls

♂ • tufting and intraepithelial lumen formation, cellular atypia with enlarged, hyperchromatic nuclei of variable shapes and sizes are frequently observed

abnormal prostate gland ventral lobe morphology ( J:96117 )

♂

prostate gland ventral lobe hyperplasia ( J:96117 )

♂ • epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks

increased prostate gland tumor incidence ( J:96117 )

♂ • at 1 year all males show primary prostate tumors with associated lymphocytic invasion

increased prostate gland adenocarcinoma incidence ( J:96117 )

♂ • tumors are adenocarcinomas

reproductive system

abnormal prostate gland epithelium morphology ( J:96117 )

♂ • epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks; lesions present as disorganized layers of epithelial cells in contrast to single regular layer observed in controls

♂ • tufting and intraepithelial lumen formation, cellular atypia with enlarged, hyperchromatic nuclei of variable shapes and sizes are frequently observed

abnormal prostate gland ventral lobe morphology ( J:96117 )

♂

prostate gland ventral lobe hyperplasia ( J:96117 )

♂ • epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks

increased prostate gland tumor incidence ( J:96117 )

♂ • at 1 year all males show primary prostate tumors with associated lymphocytic invasion

increased prostate gland adenocarcinoma incidence ( J:96117 )

♂ • tumors are adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:96117