Phenotypes Associated with This Genotype

Genotype
MGI:3831310

• Allelic Composition: Tg(Pbsn-IGF1*)5305Ng/0; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:144539 )

♂

abnormal metastatic potential ( J:144539 )

♂ • by 24 weeks, mice show metastatic deposits in pelvic lymph nodes, renal lymph nodes, lungs, salivary glands and liver while TRAMP littermates primarily show deposits in the pelvic lymph nodes

decreased tumor incidence ( J:144539 )

♂ • fewer multi-lobe tumors develop at 18 and 24 weeks (14 and 57% respectively) than in hemizygous TRAMP littermates (45 and 86%, respectively)

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:144539 )

♂

reproductive system

increased prostate gland tumor incidence ( J:144539 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:144539