Phenotypes Associated with This Genotype

Genotype
MGI:3831430

• Allelic Composition: Brca2^tm1Brn/Brca2^tm1Brn; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:73028 )

• mice develop tumors with a short median latency period of 181 days

• tumors exhibit expansive growth pattern, a high nuclear grade, and a high mitotic index

increased mammary gland tumor incidence ( J:73028 )

• in 72% of mice

increased mammary adenocarcinoma incidence ( J:73028 )

increased skin tumor incidence ( J:73028 )

• mice develop skin carcinomas

integument

increased mammary gland tumor incidence ( J:73028 )

• in 72% of mice

increased mammary adenocarcinoma incidence ( J:73028 )

increased skin tumor incidence ( J:73028 )

• mice develop skin carcinomas

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:73028 )

• in 72% of mice

increased mammary adenocarcinoma incidence ( J:73028 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:73028