Phenotypes Associated with This Genotype

Genotype
MGI:3832389

• Allelic Composition: Ldb3^tm4Chen/Ldb3^tm4Chen; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144739 )

• all die between 16 and 23 weeks of age

cardiovascular system

abnormal myocardial fiber morphology ( J:144739 )

• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen

• however M-lines are relatively normal

enlarged heart ( J:144739 )

• enlarged left and right ventricles

increased heart weight ( J:144739 )

• the ratios of heart weight to body weight and heart weight to tibia bone length are increased

cardiac hypertrophy ( J:144739 )

abnormal heart ventricle morphology ( J:144739 )

thin interventricular septum ( J:144739 )

• thinner at end diastole compared to controls

abnormal heart left ventricle morphology ( J:144739 )

• significant increase in left ventricular dimension at end diastole and end systole

• enlarged with a thinner wall

• increase in left ventricle size is seen in mice at 2 - 4 months of age but not at 1 month of age

abnormal heart right ventricle morphology ( J:144739 )

• enlarged with a thinner wall

thin ventricular wall ( J:144739 )

• in both the left and right ventricles

dilated cardiomyopathy ( J:144739 )

atrioventricular block ( J:144739 )

• electrocardiography reveals an atrioventricular block

muscle

abnormal myocardial fiber morphology ( J:144739 )

• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen

• however M-lines are relatively normal

dilated cardiomyopathy ( J:144739 )

growth/size/body

enlarged heart ( J:144739 )

• enlarged left and right ventricles

increased heart weight ( J:144739 )

• the ratios of heart weight to body weight and heart weight to tibia bone length are increased

cardiac hypertrophy ( J:144739 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1C		DOID:0110423	OMIM:601493	J:144739