Phenotypes Associated with This Genotype

Genotype
MGI:3832390

• Allelic Composition: Ldb3^tm4Chen/Ldb3^tm4Chen; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144739 )

• all mice die between 1 and 16 weeks after tamoxifen treatment

cardiovascular system

enlarged heart ( J:144739 )

• after tamoxifen treatment

dilated heart left ventricle ( J:144739 )

• both ventricles are severely dilated after tamoxifen treatment

dilated heart right ventricle ( J:144739 )

• both ventricles are severely dilated after tamoxifen treatment

abnormal cardiovascular system physiology ( J:144739 )

• decreased heart function one month after tamoxifen treatment

dilated cardiomyopathy ( J:144739 )

• after tamoxifen treatment

muscle

dilated cardiomyopathy ( J:144739 )

• after tamoxifen treatment

growth/size/body

enlarged heart ( J:144739 )

• after tamoxifen treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1C		DOID:0110423	OMIM:601493	J:144739