Phenotypes Associated with This Genotype

Genotype
MGI:3832892

• Allelic Composition: Tg(Thy1-MAPT*V337M)1Godt/0
• Genetic Background: involves: C57BL/6J * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:143018 )

N • mice exhibit normal motor functions

abnormal impulsive behavior control ( J:143018 )

• in 5-choice serial reaction time task (5-CSRTT), old mice exhibit increased impulsive behaviors compared to wild-type mice

• in 5-CSRTT tests with task manipulations, young and old mice exhibit increased impulsive behavior compared to wild-type mice

• increased impulsive behaviors are exacerbated by age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255	OMIM:600274	J:143018