Phenotypes Associated with This Genotype

Genotype
MGI:3833108

• Allelic Composition: Tg(SOD1*H46R*H48Q)58Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:119631 )

• astrogliosis is observed in the cortical and hippocampal brain regions, the ventral midbrain, brain stem and spinal cord unlike in wild-type mice

decreased motor neuron number ( J:119631 )

• in the spinal cord of paralyzed mice

behavior/neurological

hindlimb paralysis ( J:119631 )

• at 4 to 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:119631