Phenotypes Associated with This Genotype

Genotype
MGI:3833892

cn2

• Allelic Composition: Supv3l1^tm2.1Jkl/Supv3l1^tm2.2Jkl; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skin abnormalities in various conditional Supv3l1 mutants

adipose tissue

adipose tissue phenotype ( J:144991 )

N • unlike in Supv3l1^tm2Jkl/Supv3l1^tm2Jkl floxed Tg(Mx1-cre)1Cgn mice, tamoxifen-treated mice exhibit normal growth, body composition, and weights

cardiovascular system

dilated vasculature ( J:144991 )

• in the ears of tamoxifen-treated mice

integument

integument phenotype ( J:144991 )

N • unlike in Supv3l1^tm2Jkl/Supv3l1^tm2Jkl floxed Tg(Mx1-cre)1Cgn mice, tamoxifen-treated mice exhibit normal hair growth

abnormal dermal layer morphology ( J:144991 )

• the ears of tamoxifen-treated mice exhibit chronic inflammation with marked apoptosis and focal intraepithelial lymphocyte infiltrate unlike in mice heterozygous for the floxed allele

hyperkeratosis ( J:144991 )

• the ears of tamoxifen-treated mice

parakeratosis ( J:144991 )

• the ears of tamoxifen-treated mice

acanthosis ( J:144991 )

• the ears of tamoxifen-treated mice

thick epidermis ( J:144991 )

• the ears of tamoxifen-treated mice

reddish skin ( J:144991 )

• the ears of tamoxifen-treated mice are disfigured and have erythromatous swelling unlike in mice heterozygous for the floxed allele

scaly skin ( J:144991 )

• the ears of tamoxifen-treated mice