Phenotypes Associated with This Genotype

Genotype
MGI:3834482

• Allelic Composition: Tg(Ly6a-BCR/ABL1)IS1BIsg/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144382 )

• mice die by 18 months of age

• 30% of mice die due to kidney failure from myeloid infiltrates in the kidney

• 70% of mice die from progression to blast crisis

• treatment with STI571 does not alter survival

neoplasm

increased testis tumor incidence ( J:144382 )

♂ • Sertoli cell tumors develop in 2% of mice

increased hepatoma incidence ( J:144382 )

• 3% of mice develop hepatocarcinoma

increased chronic myelocytic leukemia incidence ( J:144382 )

• all mice develop chronic myeloid leukemia by 4 to 10 months of age with progression to blast crisis

• myeloid and lymphoid blasts appear in the peripheral blood, bone marrow, spleen, and liver

• leukemia can be induced in wild-type mice by engraftment of Sca+Lin- cells but not Sca-Lin+ cells

increased lung adenocarcinoma incidence ( J:144382 )

• in 10% of mice

increased osteosarcoma incidence ( J:144382 )

• in 2% of mice

immune system

increased leukocyte cell number ( J:144382 )

increased neutrophil cell number ( J:144382 )

abnormal spleen morphology ( J:144382 )

• spleens contain megakaryocyte as markers of myeloid metaplasia

increased spleen weight ( J:144382 )

increased spleen red pulp amount ( J:144382 )

• spleens contain megakaryocyte as markers of myeloid metaplasia

abnormal lymph node morphology ( J:144382 )

• contains myeloid cells

cellular

abnormal chromosome morphology ( J:144382 )

• centromere abnormalities are detected in 24% chronic phase cells and 62% of acute phase cells compared to 3% of wild-type cells

liver/biliary system

abnormal liver morphology ( J:144382 )

• livers contain megakaryocyte as markers of myeloid metaplasia

increased hepatoma incidence ( J:144382 )

• 3% of mice develop hepatocarcinoma

renal/urinary system

kidney failure ( J:144382 )

• 30% of mice die due to kidney failure from myeloid infiltrates in the kidney

respiratory system

abnormal lung morphology ( J:144382 )

• contains myeloid cells

increased lung adenocarcinoma incidence ( J:144382 )

• in 10% of mice

hematopoietic system

increased leukocyte cell number ( J:144382 )

increased neutrophil cell number ( J:144382 )

abnormal spleen morphology ( J:144382 )

• spleens contain megakaryocyte as markers of myeloid metaplasia

increased spleen weight ( J:144382 )

increased spleen red pulp amount ( J:144382 )

• spleens contain megakaryocyte as markers of myeloid metaplasia

skeleton

increased osteosarcoma incidence ( J:144382 )

• in 2% of mice

growth/size/body

increased spleen weight ( J:144382 )

reproductive system

increased testis tumor incidence ( J:144382 )

♂ • Sertoli cell tumors develop in 2% of mice

endocrine/exocrine glands

increased testis tumor incidence ( J:144382 )

♂ • Sertoli cell tumors develop in 2% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:144382